We adopted the opportunity cost approach and used average wages to reflect this value. The healthcare costs per extra person with a clinically significant reduction in fatigue and disability are also shown. The effectiveness data came from a study (PACE RCT) which had a strong methodological design, was well reported and outlined steps taken to control for potential confounders at the design and analysis stage. This is a recommended method in England, but the sensitivity of the measure in relation to changes in clinical measures in the CFS area has not yet been established. See more; The Lancet (2011) 377(9768) 823-836. Interpretation of the cost-effectiveness results was made using cost-effectiveness acceptability curves [18]. The authors' conclusions appear appropriate, although they may be limited by the short time frame. We would like to thank all members of the PACE trial management group. Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT. 2018 Jun 1;41(8):959-66. doi: 10.1111/pace.13401. Patients in the SMC group had the lowest level of receipt at baseline but the figures at follow-up were similar between groups. McCrone P, Sharpe M, Chalder T, Knapp M, Johnson AL, Goldsmith KA, White PD. Comparisons were made between SMC alone and each of APT, CBT and GET. In our analysis we adopted both a healthcare and a societal perspective. Days lost by patients from work, and reduced hours while at work, due to fatigue were also recorded. DOI: 10.1016/S0140-6736(11)60096-2. Two variables were created to indicate whether patients achieved a two-point improvement on the Chalder fatigue questionnaire (CFQ) and an eight-point change on the Short Form-36 physical function sub-scale (SF36 PF) [7], [8]. Adding cognitive behaviour therapy or graded exercise therapy to specialist medical care was found to be more effective in reducing both fatigue and disability than adding adaptive pacing therapy or specialist care alone.

During adaptive LV-only pacing, the atrial-to-RV sense interval (measured every minute) is used to deliver LV paces at least 40 ms before the anticipated RV sense. NCI CPTC Antibody Characterization Program. 2018 Jul;23(4):537-545. doi: 10.1007/s10741-018-9712-1. https://doi.org/10.1371/journal.pone.0040808, Editor: Pieter H. M. van Baal, The healthcare costs per QALY gained for CBT and GET compared to SMC were below the cost-effectiveness threshold of £30,000. Confidence intervals were generated around the cost differences using non-parametric bootstrapping. Background The PACE trial compared the effectiveness of adding adaptive pacing therapy (APT), cognitive behaviour therapy (CBT), or graded exercise therapy (GET), to specialist medical care (SMC) for patients with chronic fatigue syndrome. https://doi.org/10.1371/journal.pone.0040808.g002. The study compared the cost-effectiveness of adding adaptive-pacing therapy, cognitive behavioural therapy (CBT), or graded-exercise therapy to specialist medical care for adult patients with chronic fatigue syndrome in the UK from two alternative perspectives (health care and societal). Erasmus University Rotterdam, The Netherlands, Received: February 8, 2012; Accepted: June 13, 2012; Published: August 1, 2012.

During negotiations with the journal over these matters, we have sought further guidance from the PACE trial REC. However, only a minority of patients in both of these studies had CFS and neither used QALYs as an outcome measure.



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